罗周卿 教授
邮 箱：luozq@xmu.edu.cn
职称/职务：教授
联系方式：
个人简介
2012年，厦门大学生物学专业，学士学位；
2017年，清华大学生物学专业，博士学位；
2017-2021年，中国科学院深圳先进技术研究院，博士后/副研究员；
2022年至今，厦门大学生命科学学院，教授；
B.S. 2012, Xiamen University, Biology;
Ph.D. 2017, Tsinghua University, Biology;
Postdoctoral Fellow/Associate Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 2017-2021;
Professor, School of Life Sciences, Xiamen University, 2022 to Present.
科研领域
基因组的设计与合成可显著扩大序列改造的规模，有望突破现有的基因组功能认知，拓展人工生命体的应用。课题组负责人前期参与了世界首个真核生物基因组合成计划，构建了迄今为止最长的真核生物线性合成染色体，首次鉴定了组蛋白2-hydroxyisobutyrylation的修饰酶和去修饰酶，开创的MRA 层级组装技术和ReSCuES筛选技术解决了合成染色体设计、构建和应用等方面的系列难点，成果发表在Science（封面专刊）、Cell Res、Nat Commun和Genome Biol等期刊上。研究成果获得深圳市自然科学一等奖，入选2017年度中国高等学校十大科技进展和中国科学十大进展。本课题组未来将继续致力于基因组相关的基础理论研究、关键技术突破和新型应用开发。
Synthetic genomics is an important part of synthetic biology, which is expected to innovate our understanding about genome function and to significantly improve the depth and ability of genome engineering. We participated in the world's first eukaryotic genome synthesis project, constructed the longest eukaryotic linear synthetic chromosome so far, identified the Writers and Erasers of histone 2-hydroxyisobutyrylation, and created technologies for synthetic chromosome design, construction and application. Our results have been published in journals such as Science (cover story and special issue), Cell Res, Nat Commun and Genome Biol. In the future, our research group will continue to focus on the basic theories, key technologies and new applications related to genome.
代表性论文(#co-first author,*Corresponding author)
1. W. Zhang*, G. Zhao*, Z. Luo*, Y. Lin, L. Wang, Y. Guo, A. Wang, S. Jiang, Q. Jiang, J. Gong, Y. Wang, S. Hou, J. Huang, T. Li, Y. Qin, J. Dong, Q. Qin, J. Zhang, X. Zou, X. He, L. Zhao, Y. Xiao, M. Xu, E. Cheng, N. Huang, T. Zhou, Y. Shen, R. Walker, Y. Luo, Z. Kuang, L.A. Mitchell, K. Yang, S.M. Richardson, Y. Wu, B.-Z. Li, Y.-J. Yuan, H. Yang, J. Lin, G.-Q. Chen, Q. Wu, J.S. Bader, Y. Cai, J.D. Boeke, J. Dai#, Engineering the ribosomal DNA in a megabase synthetic chromosome, Science.355 (2017) eaaf3981.
2. Y. Shen*, Y. Wang*, T. Chen*, F. Gao, J. Gong, D. Abramczyk, R. Walker, H. Zhao, S. Chen, W. Liu, Y. Luo, C.A. Müller, A. Paul-Dubois-Taine, B. Alver, G. Stracquadanio, L.A. Mitchell,Z. Luo, Y. Fan, B. Zhou, B. Wen, F. Tan, Y. Wang, J. Zi, Z. Xie, B. Li, K. Yang, S.M. Richardson, H. Jiang, C.E. French, C.A. Nieduszynski, R. Koszul, A.L. Marston, Y. Yuan, J. Wang, J.S. Bader, J. Dai, J.D. Boeke, X. Xu, Y. Cai#, H. Yang#, Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome, Science. 355 (2017) eaaf4791.
3. G. Mercy*, J. Mozziconacci*, V.F. Scolari, K. Yang, G. Zhao, A. Thierry, Y. Luo, L.A. Mitchell, M. Shen, Y. Shen, R. Walker, W. Zhang, Y. Wu, Z. Xie,Z. Luo, Y. Cai, J. Dai, H. Yang, Y.-J. Yuan, J.D. Boeke, J.S. Bader, H. Muller#, R. Koszul#, 3D organization of synthetic and scrambled chromosomes, Science. 355 (2017) eaaf4597.
4. Z. Luo*, L. Wang*, Y. Wang, W. Zhang, Y. Guo, Y. Shen, L. Jiang, Q. Wu, C. Zhang, Y. Cai#, J. Dai#, Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES, Nat. Commun.9 (2018) 1930.
5. W. Liu*,Z. Luo, Y. Wang, N.T. Pham, L. Tuck, I. Pérez-Pi, L. Liu, Y. Shen, C. French, M. Auer, J. Marles-Wright, J. Dai#, Y. Cai#, Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods, Nat. Commun.9 (2018) 1936.
6. Z. Luo#*, K. Yu*, S. Xie, M. Monti, D. Schindler, Y. Fang, S. Zhao, Z. Liang, S. Jiang, M. Luan, C. Xiao, Y. Cai#, J. Dai#, Compacting a synthetic yeast chromosome arm, Genome Biol.22 (2021) 1-18.
7. J. Huang*, Z. Luo*, W. Ying*, Q. Cao, H. Huang, J. Dong, Q. Wu, Y. Zhao, X. Qian#, J. Dai#, 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci. 114 (2017) 8782–8787.
8. H. Huang*, Z. Luo*, S. Qi*, J. Huang*, P. Xu, X. Wang, L. Gao, F. Li, J. Wang, W. Zhao, W. Gu, Z. Chen, L. Dai#, J. Dai#, Y. Zhao#, Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway, Cell Res. 28 (2018) 111–125.
9. Y. Wang*, W. Li*, A.E. Johnson*, Z. Luo*, X. Sun, A. Feoktistova, W.H. McDonald, I. McLeod, J.R. Yates, K.L. Gould, D. McCollum#, Q. Jin#, Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast, Mol. Biol. Cell. 23 (2012) 3348–3356.
10. Z. Luo, J. Dai, Synthetic genomics: the art of design and synthesis, Chin. J. Biotechnol. 33 (2017) 331–342.
11. Z. Luo, Q. Yang, B. Geng, S. Jiang, S. Yang, X. Li, Y. Cai, J. Dai#, Whole genome engineering by synthesis, Sci. China Life Sci. (2018).1515–1527.
12. J. Lu, Z. Luo, S. Jiang, Y. Shen, Y. Wu, H. Yang, Y. Yuan, J. Dai#, Technologies for DNA Synthesis, Assembly, and Transplantation. Bulletin of Chinese Academy of Sciences, 33(2018) 1174-1183.
13. B. Li, Y. Wu, Z. Xie, Y. Shen, Y. Wang, W. Zhang, G. Zhao, Z. Luo, J. Dai, H. Yang, Y. Yuan#, Precise Synthesis of Designer Large Chromosomes of Saccharomyces cerevisiae. Frontier Science, 12(2018) 55-59.
14. Z. Luo, S. Hoffmann, S. Jiang, Y. Cai#, J. Dai#. Probing eukaryotic genome functions with synthetic chromosomes. Exp Cell Res. 390(2020) 111936.
15. J. Dai, J.D. Boeke, Z. Luo, S. Jiang, Y. Cai#, Sc3.0: revamping and minimizing the yeast genome, Genome Biol. 21(2020) 1-4.
16. Z. Luo, S. Jiang, J. Dai, Chromosomal Rearrangements of Synthetic Yeast by SCRaMbLE, Methods Mol Biol. 2021;2196:153-165.
17. S. Jiang, Z. Luo, J. Dai. Use YeastFab to Construct Genetic Parts and Multicomponent Pathways for Metabolic Engineering, Methods Mol Biol. 2021;2196:167-180.
荣誉、奖励及参加学术团体的情况
Sc2.0 Fellowship Award (University of Edinburgh)，2016年
2017 Cold Spring Harbor Asia Fellowship Award，2017年
