邵晨

研究领域（200~300字介绍）：

1. 泌尿生殖系肿瘤转移机制及循环肿瘤细胞分子特性

开展肾癌靶向药物耐受相关的分子机制研究；循环肿瘤细胞的检测在肾癌临床诊断及治疗中的应用；前列腺癌循环肿瘤细胞分子特性及其在转移过程中的对靶器官的识别、定位；高危前列腺癌进展及转移机制研究等。

2. 泌尿系肿瘤分子成像相关研究

开展近红外荧光染料NIR-dye对肿瘤细胞的特异性转运、富集、靶向的机制和应用研究；近红外荧光染料与小分子抑制剂偶联对肿瘤的发生、发展、抑制作用及转移定位、追踪等相关研究。

学习经历

1.1987.8 – 1993.08第四军医大学，临床医学（六年制），学士

2.1995.8 – 2000.08第四军医大学，泌尿外科学，博士(硕博连读)

工作经历

1.2017.05 -至今 厦门大学附属翔安医院副院长、泌尿外科主任 教授、主任医师

2.2010.9-2017.5,第四军医大学第一附属医院泌尿外科,教授/主任医师

3.2005.9-2010.9,第四军医大学,第一附属医院泌尿外科,副教授/副主任医师

4. 2000.9-2005.9,第四军医大学第一附属医院泌尿外科,讲师/主治医师

5. 1993.9-2000.9,第四军医大学第一附属医院,助教/住院医师

6. 2010.10-2012.6,美国Cedars-Sinai医学中心,博士后,合作导师: Lenland WK Chung

代表性成果：

1. Yue J, Sun H, Liu S, Yu F, Wang S, Wang F, Shen R, Zhu F, Zhang L, Shao C. Downregulation of NDR1 contributes to metastasis of prostate cancer cells via activating epithelial-mesenchymal transition. Cancer Med. 2018 May 7. doi: 10.1002/cam4.1532.(通讯作者) (IF 3.362)

2. Liu SJ ,Tian ZH, Zhang L, Hou S, Hu SJ, Wu JS, Jing YM , Sun HM , Yu F, Zhao LB , Wang RX , Tseng HR ,.Zhau HE , Chung Leland W.K., Wu KC, Wang H , Wu Jason B , Nie YZ ,Shao C*.Combined cell surface carbonic anhydrase 9 and CD147 antigens enable high-efficiency capture of circulating tumor cells in clear cell renal cell carcinoma patients. Oncotarget 2016;7(37):59877-59891.(通讯作者) (IF 5.008)

3. Sun H^#, Zhang L^#, Shi C, Hu P, Yan W, Wang Z, Duan Q, Lu F, Qin L, Lu T, Xiao J, Wang Y, Zhu F*,Shao C*.TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer. Oncotarget 2015;20;6(14):12392-404.(通讯作者) (IF 6.627)

4. Liu SJ, Qiao SL, Li LL, Qi GB, Lin YX, Qiao ZY, Wang H,Shao C*. Surface charge-conversion polymeric nanoparticles for photodynamic treatment of urinary tract bacterial infections. Nanotechnology.(通讯作者) (IF 3.821)

5. Wu JB^#,Shao C^#,Li X, Shi C,Li Q,Hu P,Chen YT,Dou X,Sahu D,Li W,Harada H,Zhang Y, Wang R, Zhau HE, Chung LW*. Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis. Biomaterials. 2014 ;20.(14)00630-9.（共同第一）(IF 8.312)

6. Xiao JJ, Duan Q, Wang Z, Yan W, Sun HM , Xue PP , Fan XM ,Zeng XY ,Chen J , ChenShao C*, Zhu F Phosphorylation of TOPK at Y74, Y272 by Src Increases the Stability of TOPK and Promotes Tumorigenesis of Colon Cancer. Oncotarget. 2016;7(17):24483-94. (共同通讯) (IF 6.359).

7. Zhang L^#, Ji G^#, Shao Y^#, Qiao S, Jing Y, Qin R, Sun H,Shao C*. MLF1 Interacting Protein: a Potential Gene Therapy Target for Human Prostate Cancer? Medical Oncol. 2015 ;32(2):454. doi: 10.1007/s12032-014-0454-1.(通讯作者) (IF 2.058)

8. Shao C^#, Liao CP^#, Hu P, Ng CS, Josephson DY, Knudsen B, Tighiouart M, Kim HL, Zhau HE, Chung LW*, Wang R*, Posadas EM*. Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer. PLoS One.2014;14;9(2). e8896.（第一作者）(IF 3.534)

9. Shao C^#, Wang Y^#, Yue HH, Zhang YT, Shi CH, Liu F, Bao TY, Yang ZY, Yuan JL, Shao GX. Biphasic effect of androgens on prostate cancer cells and its correlation with androgen receptor coactivatordopa decarboxylase. J Androl, 2007,28(6), 804-12.（第一作者）(IF2.473)

10. Lu YT^#, Zhao L^#,Shen Q^#, Garcia MA^#,Wu D, Hou S,Song M, Xu X, Ouyang WH, Ouyang WW, Lichterman J, Luo Z, Xuan X, Huang J, Chung LW, Rettig M*,Tseng HR*,Shao C*, Posadas EM*. NanoVelcro Chip for CTC enumeration in prostate cancer patients. Methods. 2013 ;64(2):144-52.(共同通讯) (IF 3.221)

11. Zhang L^#, Zhang WL^#,Shao C^#,Zhang J,Men K,Shao Z,Yan Y,Xu D*.Establishment and characterization of a spontaneously immortalized trophoblast cell line (HPT-8) and its hepatitis B virus-expressing clone. Hum Reprod. 2011;26(8):2146-56.（共同第一）(IF 4.585)

12. Yang XJ^#,Shao C^#, Wang R, Chu CY, Hu P, Master V, Osunkoya AO, Kim HL, Zhau HE, Chung LW*. Optical imaging of kidney cancer with novel near-infrared heptamethine carbocyanine fluorescent dyes. J Urol. 2013:189(2):702-10.（共同第一）(IF 5.157)

13. Dou XL^#,Qin RL^#,Qu J,Liao YH,Lu Yc,Zhang T,Shao C*,Li YQ*. Synaptic Connections between Endomorphin 2-Immunoreactive Terminals and mu-Opioid Receptor-Expressing Neurons in the Sacral Parasympathetic Nucleus of the Rat. PLoS One.2013;8(5):e62028 .(共同通讯) (IF 3.534)

14. Wu JB^#,Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles BL, Zhau HE*, Shih JC*, Chung LW*. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis.J Clin Invest.2014;1;124(7):2891-908.(IF 13.765)

15. Josson S^#, Gururajan M^#, Hu P,Shao C, Chu CY, Zhau HE, Liu C, Lao K, Lu CL, Lu YT, Lichterman J, Nandana S, Li Q, Rogatko A, Berel D, Posadas EM, Fazli L, Sareen D, Chung LW*.miR-409-3p/-5p promotes tumorigenesis, epithelial to mesenchymal transition and bone metastasis of human prostate cancer. Clin Cancer Res. 2014;1;20(17):4636-46.(IF 8.193)

16. Zhao L, Lu YT, Li F, Wu K, Hou S, Yu J, Shen Q, Wu D, Song M, Ouyang WH, Luo Z, Lee T, Fang X,Shao C, Xu X, Garcia MA, Chung LW, Rettig M, Tseng HR, Posadas EM. High-Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber-Embedded Microchip for Whole Exome Sequencing. Advanced Materials, 2013 ;25(21):2897-902.(IF 14.829)

17. Vishchuk OS#, Sun H#, Wang Z, Ermakova SP, Xiao J, Lu T, Xue P, Zvyagintseva TN, Xiong H,Shao C, Yan W, Duan Q, Zhu F. PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth. Oncotarget 2016:7(14):18763-18773.

主持过的重要课题：

1.国家自然科学基金青年项目 《人前列腺癌细胞雄激素依赖性转化的机理》（30100185）2001/01-2003/12 主持

2.国家自然科学基金面上项目 《新的前列腺癌细胞DU-145凋亡相关基因pcar表达及功能研究》(30271302) 2002/01-2004/12 主持

3.国家国际科研合作与交流重大项目 《循环肿瘤细胞在前列腺癌骨转移发生机制的合作研究》（2011DFA33110）2013-2016 主持

4.国家自然科学基金面上项目 《新的TOPK磷酸化位点S32参与高危前列腺癌进展及转移的机制和功能研究》（81572529）2016/01-2019/12 主持

已申请的专利：

1.发明专利：成人肾母细胞瘤HANB细胞株及其培养方法和应用（ZL2011108338153.3）

2.新型专利：螺纹型多槽式导尿装置（ZL201120253591.5）

3.新型专利：基化改性的壳聚糖涂层尿道支架（ZL201120264070.X）

4.发明专利：前列腺癌循环肿瘤细胞PC3-CTC细胞株的建立及其培养方法（已报）

5.发明专利:一种具有pH响应性及光敏性的抗菌材料及其制备方法(ZL20151077187.7)

6.新细胞株：《小鼠前列腺癌循环肿瘤细胞PC3-CTC分离及培养方法》（武汉大学细胞典藏中心保藏号CCTCC NO:C201601）