徐立

研究领域：

长期从事胃肠道疾病和肿瘤的基础及临床研究，在肿瘤的预防和治疗、新药开发和临床试验等方面积累了丰富的经验。近年来临床上主要致力于常见胃肠道疾病的诊治和消化系统恶性肿瘤规范化和个体化治疗。

在基础研究方面，率先系统解析了由转化生长因子β介导的前列腺癌转移的分子机制，详尽探讨了染料木黄酮genistein，一种大豆提取物，抑制前列腺癌转移的靶向分子；揭示了分子变异、药物剂量与生物学活性的关系，为肿瘤的个体化治疗提供了理论基础；通过细胞体外实验、动物体内实验和II期临床试验，多层次、多方位地论证了genistein在前列腺癌转移防治中的重要作用；根据genistein的分子结构，深入剖析了分子的构效关系，筛选出具有高效转移抑制活性但无雌激素副作用的新药，为药物的活性优化探索出一条新路，相关文章发表在Nature Communications等杂志上。

学习经历

1999 医学博士 第四军医大学西京医院消化内科，中国西安

1996 医学硕士 第四军医大学西京医院消化内科，中国西安

1993 医学学士 第四军医大学，中国西安

工作经历

2018.04---至今 副教授、副主任医师

厦门大学附属翔安医院，中国福建

2017.03---2018.04副教授、副主任医师

西京消化病院，中国西安

2010.09---2017.03副教授、主治医师

西京消化病院，中国西安

2008.09---2012.04 Research Assistant Professor

Division of Hematology/Oncology

Department of Medicine,

Robert H. Lurie Cancer Center

Northwestern University, USA

2004.10---2008.08 Research Associate

Division of Hematology/Oncology

Department of Medicine,

Robert H. Lurie Cancer Center

Northwestern University, USA

2003.08---2004.09 Postdoctoral Fellow

Division of Hematology/Oncology

Department of Medicine,

Robert H. Lurie Cancer Center

Northwestern University, USA

1999.07---2003.08讲师、主治医师

西京医院消化病研究所，中国西安

代表性成果：

· Xu L, Gordon R, Farmer R, Pattanayak A, Binkowski A, Huang X, Avram M, Krishna S, Voll E, Pavese J, Chavez J, Bruce J, Mazar A, Nibbs A, Anderson W, Li L, Jovanovic B, Pruell S, Valsecchi M, Francia G, Betori R, Scheidt K, Bergan R. Precision therapeutic targeting of human cancer cell motility. Nature Communications. 2018, 9(1):2454-68

· Xiao X, Liu Z, Wang R, Wang J, Zhang S, Cai X, Wu K, Bergan RC, Xu L, Fan D. Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis. Oncotarget. 2015,6(5):3225-39

· Xiao X, Gang Y, Wang H, Wang J, Zhao L, Xu L, Liu Z. Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy. Biochem Biophys Res Commun. 2015,457(2):221-6.

· Liu D, Xu LW, Yin ZY, Huang YY, Xu L. Preliminary Assessment for Attitudes of Medical Students to Doctor-Patient Communication. Science Journal of Education. 2016; 4(3): 113-117

· Li T, Wang H, Sun Y, Zhao L, Gang Y, Guo X, Huang R, Yang Z, Pan Y, Wu K, Xu L, Liu Z, and Fan D. Transcription Factor CUTL1 Is a Negative Regulator of Drug Resistance in Gastric Cancer. The Journal of Biological Chemistry. 2013, 288(6): 4135-4147

· Xu L, Wang SS, Healey MA, Faupel-Badger JM, Wilken JA, Battaglia T, Szabo E, Mao JT, Bergan RC. The Ninth Annual American Association of cancer research international conference on frontiers in cancer prevention research (meeting report). Cancer Prevention Research（Cancer Prev Res (Phila)）. 2011,4(4):616-21

· Xu L, Ding Y, Catalona WJ, Yang XJ, Anderson WF, Jovanovic B, Wellman K, Kilmer J, Huang X, Scheidt KA, Montgomery RB, Bergan RC. MEK4 function, genistein treatment, and invasion of human prostate cancer cells. Journal of the National Cancer Institute (J Natl Cancer Inst.）2009, 101(16):1141-55.

· Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, and Bergan RC. Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Research. 2008, 68(6):2024-32.

· Craft CS, Xu L, Romero D, Vary CP and Bergan RC. Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells. Molecular Pharmacology. 2008, 73(1):235-242.

· Ding Y, Xu L, Jovanovic BD, Helnowski IB, Kelly DL, Catalona WJ, Yang XJ, Pins M, and Bergan RC. The methodology used to measure differential gene expression affects the outcome. Journal of Biomolecular Techniques. 2007, 18(5):321-330.

· Xu L and Bergan RC. Genistein inhibits MMP-2 activation and prostate cancer cell invasion by blocking TGFb-mediated activation of the MAPKAPK2-HSP27 pathway. Molecular Pharmacology. 2006, 70(3):869-877.

· Xu L, Chen S and Bergan RC. MAPKAPK2 and HSP27 are downstream mediators of TGF-dependent cell invasion in human prostate cancer. Oncogene. 2006, 25(21):2987-2998.

· Ding Y, Xu L, Chen S, Jovanovic BD, Helnowski IB, Kelly DL, Catalona WJ, Yang XJ, Pins M, Ananthanarayanan V and Bergan RC. Characterization of a method for profiling gene expression in cells recovered from intact human prostate tissue using RNA linear amplification. Prostate Cancer and Prostatic Diseases. 2006, 9(4):379-391.

· Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC and Bergan RC. Genistein inhibits p38 MAP kinase activation, MMP-2, and cell invasion in human prostate. Cancer Research. 2005, 65(8):3470-3478. PMID: 15833883 IF:7.616

· Xu L, Jin BQ and Fan DM. Identification of Mimic Epitopes for Gastric Cancer Associated Antigen MG7 Antigen. Molecular Cancer Therapeutics. 2003, 2(3): 301-306

主持过的重要课题：

· STIM1相关信号通路调控结直肠癌转移机制研究 No. 81472300国家自然科学基金面上项目主负责人 2015.01---2018.12在研

· 利用TFD策略研究影响胃癌阿霉素敏感性的关键转录因子亚群 No.81272449国家自然科学基金面上项目 主负责人 2013.01---2016.12结题

· 一个新的肝纤维化相关分子OPN在TGF-β1介导的肝纤维化中的分子机制研究 No.81070350 国家自然科学基金面上项目 主负责人 2011.01---2013.12 结题

· 新型胃癌特异的嵌合锚定T细胞构建及杀伤活性研究 No.39900068国家自然科学基金青年科学基金项目主负责人 2000.01---2002.12结题

已申请的专利：

Inhibition of Cancer Cell Motility (U.S. Patent Application No.: 14/935,040/awarded 8/2017; U.S. Patent No. 9,839,625 ). Role: inventor（third）